The Cardinals' offense came to life early in Wednesday's opener. Jim Edmonds three-run shot in the first inning gave starter Chris Carpenter all the support he would need. Carpenter, who missed all of the 2004 postseason, limited the Astros to one run on four hits in seven innings in his second career Opening Day start. Reggie Sanders and Larry Walker also homered, while Albert Pujols and Scott Rolen contributed to the win with two hits each.
A sellout crowd of 43,567 turned out for Tuesday's season opener at Minute Maid Park. Craig Biggio went 3-for-4, including a two-run double in the eighth, and rookie Willy Taveras went 2-for-4, but it wasn't enough to rally the Astros back from an early deficit, despite loading the bases in the ninth. Roy Oswalt took the loss in his second Opening Day start, giving up six runs on seven hits in six innings. Houston got scoreless relief outings from Chad Harville and Dan Wheeler to keep the Astros within striking distance.