Check out the best way to get to Busch Stadium.
From I-55 South (Springfield/Bloomington/Chicago)

From I-55 North (Arnold/Festus/Cape Girardeau/Memphis, TN)

From I-64 West (Belleville/Mt. Vernon/Evansville, IN.)

From I-44 East (Kirkwood/Eureka/Springfield/Joplin)
From I-64 East (Clayton/Chesterfield)
From I-70 East (St. Charles/Wentzville/Columbia/Kansas City)
